{"id":244,"date":"2025-06-16T15:04:58","date_gmt":"2025-06-16T07:04:58","guid":{"rendered":"http:\/\/www.chunshenghouse.com\/?p=244"},"modified":"2026-03-30T14:49:54","modified_gmt":"2026-03-30T06:49:54","slug":"%e5%ae%9a%e5%88%b6%e9%a5%b2%e6%96%99%e4%b9%8b%e6%b7%bb%e5%8a%a0%e4%bb%96%e8%8e%ab%e6%98%94%e8%8a%ac%ef%bc%88tamoxifen%ef%bc%89","status":"publish","type":"post","link":"http:\/\/www.chunshenghouse.com\/index.php\/2025\/06\/16\/%e5%ae%9a%e5%88%b6%e9%a5%b2%e6%96%99%e4%b9%8b%e6%b7%bb%e5%8a%a0%e4%bb%96%e8%8e%ab%e6%98%94%e8%8a%ac%ef%bc%88tamoxifen%ef%bc%89\/","title":{"rendered":"\u5b9a\u5236\u9972\u6599\u4e4b\u6dfb\u52a0\u4ed6\u83ab\u6614\u82ac\uff08Tamoxifen\uff09"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u89c4\u683c\uff1a1kg\/\u888b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9897\u7c92\uff1a12mm\u5706\u67f1\u9897\u7c92<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"845\" height=\"1024\" src=\"http:\/\/www.chunshenghouse.com\/wp-content\/uploads\/2025\/06\/WechatIMG598-845x1024.jpg\" alt=\"\" class=\"wp-image-245\" style=\"width:258px;height:auto\" srcset=\"http:\/\/www.chunshenghouse.com\/wp-content\/uploads\/2025\/06\/WechatIMG598-845x1024.jpg 845w, http:\/\/www.chunshenghouse.com\/wp-content\/uploads\/2025\/06\/WechatIMG598-247x300.jpg 247w, http:\/\/www.chunshenghouse.com\/wp-content\/uploads\/2025\/06\/WechatIMG598-768x931.jpg 768w, http:\/\/www.chunshenghouse.com\/wp-content\/uploads\/2025\/06\/WechatIMG598.jpg 960w\" sizes=\"auto, (max-width: 845px) 100vw, 845px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Tamoxifen (ICI 47699) \u662f\u4e00\u79cd\u53e3\u670d\u6709\u6548\u7684\uff0c\u9009\u62e9\u6027\u96cc\u6fc0\u7d20\u53d7\u4f53 (estrogen receptor) \u8c03\u8282\u5242 (SERM)\uff0c\u53ef\u963b\u65ad\u4e73\u817a\u7ec6\u80de\u4e2d\u7684\u96cc\u6fc0\u7d20\u4f5c\u7528\uff0c\u5e76\u53ef\u6fc0\u6d3b\u5176\u4ed6\u7ec6\u80de\uff0c\u5982\u9aa8\u9abc\uff0c\u809d\u810f\u548c\u5b50\u5bab\u7ec6\u80de\u4e2d\u7684\u96cc\u6fc0\u7d20\u6d3b\u6027\u3002Tamoxifen \u662f\u4e00\u79cd\u6709\u6548\u7684 Hsp90 \u6fc0\u6d3b\u5242\uff0c\u53ef\u589e\u5f3a Hsp90 \u5206\u5b50\u4f34\u4fa3 ATPase \u7684\u6d3b\u6027\u3002Tamoxifen \u8fd8\u53ef\u4ee5\u6709\u6548\u6291\u5236\u4f20\u67d3\u6027 EBOV Zaire \u548c Marburg (MARV)\uff0cIC50 \u5206\u522b\u4e3a 0.1 \u03bcM \u548c 1.8 \u03bcM\u3002Tamoxifen \u53ef\u4ee5\u6fc0\u6d3b\u81ea\u566c (autophagy)\uff0c\u8bf1\u5bfc\u51cb\u4ea1 (apoptosis)\u3002Tamoxifen \u8fd8\u53ef\u4ee5\u8bf1\u5bfc CreER(T2) \u8f6c\u57fa\u56e0\u5c0f\u9f20\u7684\u57fa\u56e0\u6572\u9664\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6dfb\u52a0\u6bd4\u4f8b\uff0c\u6839\u636e\u5ba2\u6237\u7684\u9700\u6c42\u6dfb\u52a0\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5927\u90e8\u5206\u5ba2\u6237\u9009\u62e9\u7684\u662f400mg\/kg\u7684\u6dfb\u52a0\u6bd4\u4f8b<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4ed6\u83ab\u6614\u82ac\u91c7\u7528\u7684\u662f\u67b8\u6a7c\u9178\u3002\u5982\u6709\u54c1\u724c\u6216\u5176\u4ed6\u9700\u6c42\u53ef\u6c9f\u901a\uff0c\u4e5f\u53ef\u4ee5\u81ea\u5df1\u63d0\u4f9b\u4ed6\u83ab\u6614\u82ac\u7ed9\u6211\u4eec\u5236\u4f5c\u54e6\uff01<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5236\u4f5c\u8fc7\u7a0b\u4e2d\uff0c\u6839\u636e\u836f\u7269\u7684\u6027\u8d28\uff0c\u6ce8\u610f\u4e8b\u9879\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u50a8\u5b58\u6761\u4ef6\uff1a\u51b7\u85cf\u50a8\u5b58<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u89c4\u683c\uff1a1kg\/\u888b \u9897\u7c92\uff1a12mm\u5706\u67f1\u9897\u7c92 Tamoxifen (ICI 47699) \u662f\u4e00\u79cd\u53e3\u670d\u6709\u6548\u7684\uff0c\u9009\u62e9\u6027 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,98,9],"tags":[38,43],"class_list":["post-244","post","type-post","status-publish","format-standard","hentry","category-uncategorized","category-98","category-9","tag-38","tag-tamoxifen"],"_links":{"self":[{"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/posts\/244","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/comments?post=244"}],"version-history":[{"count":2,"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/posts\/244\/revisions"}],"predecessor-version":[{"id":306,"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/posts\/244\/revisions\/306"}],"wp:attachment":[{"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/media?parent=244"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/categories?post=244"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.chunshenghouse.com\/index.php\/wp-json\/wp\/v2\/tags?post=244"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}